Patient-Centered Determinants of Tuberculosis Treatment Compliance: A Five-Year Evidence Review

Abstract

Tuberculosis (TB) remains a major public health problem worldwide, with treatment adherence being critical to cure and prevention of drug resistance. Despite global DOTS strategies, non-compliance persists. This review synthesizes evidence (2019–2024) on patient-centered determinants of tuberculosis (TB) treatment compliance and contextualizes findings within Indonesia’s tuberculosis (TB) control challenges. Methods: Systematic searches were conducted in PubMed, Scopus, Web of Science, and Google Scholar. Bibliometric analyses were performed using Publish or Perish, Mendeley, and VOSviewer. 200 articles were identified, with 9693 citations (h-index 54; g-index 85). Key determinants included health literacy, stigma, mental health, socioeconomic status, family/community support, and healthcare accessibility. Digital adherence technologies (DATs) such as SMS reminders and video-supported therapy showed positive outcomes. VOSviewer mapping highlighted Chen, X as a central collaborator linking early (2020) and recent (2022) research clusters. Patient-centered determinants signifimaytly shape tuberculosis (TB) treatment compliance. Interventions combining psychosocial support, health education, and digital health are promising. Locally, patient empowerment models should complement global strategies for context-specific adherence imdemonstratement.